Study Suggests Variations in Efficacy of Higher Dose Dexamethasone for COVID-19 Patients in India

Study Suggests Variations in Efficacy of Higher Dose Dexamethasone for COVID-19 Patients in India

VoM News Desk | November 27, 2023 | 06:22 PM IST | Health | Follow on Google News

Study Suggests Variations in Efficacy of Higher Dose Dexamethasone for COVID-19 Patients in India

Study Suggests Variations in Efficacy of Higher Dose Dexamethasone for COVID-19 Patients in India

A recent study published in The Lancet Regional Health – Southeast Asia journal has revealed that a higher dose of dexamethasone might be less beneficial for COVID-19 patients in India compared to those in Europe. This finding is significant as it highlights the potential regional differences in the effectiveness of COVID-19 treatments.

Key Findings of the Study

The study, involving researchers from Copenhagen University Hospital – Rigshospitalet, Denmark, and several other institutions, analyzed the impact of a larger dose of dexamethasone (12 mg) versus the standard dose (6 mg) in Indian COVID-19 patients. It observed that the higher dose did not offer better outcomes in terms of survival rates and patient wellness after 90 and 180 days.

Considerations of Patient and Health System Differences

Researchers considered various factors, including patient demographics and health system differences between India and Europe. The study also evaluated safety and found no significant adverse effects in Indian patients with the higher dosage, which is critical for patient safety.

While the findings suggest that the higher dose of dexamethasone may not be as effective in India as in Europe, the authors note that the evidence is still weak and more research is needed to confirm these results. The study underscores the importance of understanding how treatments may vary in effectiveness across different global regions, particularly in lower-middle-income countries like India, where unique healthcare challenges exist.

Collaborative International Research Effort

The research team included experts from Apollo Hospitals in Chennai, Homi Bhabha National Institute in Mumbai, the George Institute for Global Health in New Delhi, and the University of New South Wales in Australia, reflecting a collaborative international effort to understand and improve COVID-19 treatment strategies globally.

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